A 224Ra-labeled polyoxopalladate as a putative radiopharmaceutical. Issue 53 (14th June 2019)

• Record Type: Journal Article
• Authors: Gott, Matthew; Yang, Peng; Kortz, Ulrich; Stephan, Holger; Pietzsch, Hans-Jürgen; Mamat, Constantin
• Is Part Of: Chemical communications. Volume 55:Issue 53(2019)
• Page Start: 7631
• Page End: 7634
• Publication Date: 2019-06-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc02587a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A facile preparation of polyoxopalladates with enhanced properties containing radium-224 in the core and a protein corona for further functionalization with targeting (bio)molecules for therapeutic applications in oncology is described. Abstract : Despite their attractive properties, internal targeted alpha therapies using 223/224 Ra are limited to bone-seeking applications. As there is no suitable chelator available, the search for new carriers to stably bind Ra 2+ and to connect it to biological target molecules is necessary. Polyoxopalladates represent a class of compounds where Ra 2+ can be easily introduced into the Pd-POM core during a facile one-pot preparation. Due to the formation of a protein corona, the connection to other targeting (bio)macromolecules is possible.