An easy access to topical gels of an anti-cancer prodrug (5-fluorouracil acetic acid) for self-drug-delivery applications. Issue 53 (17th June 2019)

• Record Type: Journal Article
• Authors: Chakraborty, Poulami; Dastidar, Parthasarathi
• Is Part Of: Chemical communications. Volume 55:Issue 53(2019)
• Page Start: 7683
• Page End: 7686
• Publication Date: 2019-06-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03037a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An easy access to topical gels (both hydro- and organogels) derived from an anti-cancer prodrug namely 5-fluorouracil acetic acid (5-FuA ) achieved by exploiting a simple salt formation strategy is reported for the first time. Abstract : An easy access to topical gels (both hydro- and organogels) derived from an anti-cancer prodrug namely 5-fluorouracil acetic acid (5-FuA ) achieved by exploiting a simple salt formation strategy is reported for the first time. Nearly 85% of the salts synthesized were gelators. Single crystal structures of some of the gelator salts revealed an intriguing hydrogen bonding network including double stranded 1D chains stabilized through uracil–uracil complementary interactions and the crystal structures of the gelator salts corroborated well with the hypothesis based on which the gelators were designed. Studies indicated that both the hydrogel and the methyl salicylate gel of the gelator saltFuA-15 were suitable for self-drug-delivery application.