Quantifying the benefit of a proteome reserve in fluctuating environments. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Mori, Matteo; Schink, Severin; Erickson, David; Gerland, Ulrich; Hwa, Terence
• Is Part Of: Nature communications. Volume 8:Issue 1(2017)
• Page Start: 1
• Page End: 8
• Publication Date: 2017-12
• Subjects: Biology -- Periodicals; Physical sciences -- Periodicals; 505
• DOI: 10.1038/s41467-017-01242-8
• Languages: English
• ISSNs: 2041-1723

Abstract

Abstract The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome ofEscherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility that this overexpression constitutes a strategic reserve kept by starving cells to quickly meet demand upon sudden improvement in growth conditions. For cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the allocation of the ribosomal protein reserve to maximize the overall gain in biomass during the feast. Fast-growing bacteria produce many proteins in excess of what seems optimal for exponential growth. Here, the authors present a mathematical model and experimental evidence supporting that this overexpression serves as a strategic reserve to quickly meet demand upon sudden improvement in growth conditions.