In Silico Analysis for Transcription Factors With Zn(II)2C6 Binuclear Cluster DNA-Binding Domains in Candida albicans. Issue 7 (2005)

• Record Type: Journal Article
• Authors: Maicas, Sergi; Moreno, Inmaculada; Nieto, Almudena; Gómez, Micaela; Sentandreu, Rafael; Valentín, Eulogio
• Is Part Of: Comparative and functional genomics. Volume 6:Issue 7/8(2005)
• Page Start: 345
• Page End: 356
• Publication Date: 2005
• Subjects: Genomics -- Periodicals; Genomes -- Periodicals; Cytogenetics -- Periodicals; 572.86
• DOI: 10.1002/cfg.492
• Languages: English
• ISSNs: 1531-6912

Abstract

Abstract : A total of 6047 open reading frames in the Candida albicans genome were screened forZn ( II ) 2 C 6 -type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of theCysX 2 CysX 6 CysX 5 - 16 CysX 2 CysX 6 - 8 Cys motif and a putative nuclear localization signal. Using this approach, 70 putativeZn ( II ) 2 C 6 transcription factors have been found in the genome of C. albicans .