Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility. (November 2017)

• Record Type: Journal Article
• Authors: Mao, Hailiang; Aryal, Bibek; Langenecker, Tobias; Hagmann, Jörg; Geisler, Markus; Grebe, Markus
• Is Part Of: Nature plants. Volume 3:Number 11(2017)
• Page Start: 854
• Page End: 858
• Publication Date: 2017-11
• Subjects: Plants -- Periodicals; 580.5; 580 21
• DOI: 10.1038/s41477-017-0039-z
• Languages: English
• ISSNs: 2055-0278

Abstract

Abstract The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that theArabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance. PEN3 is polarly localized at the outside of the epidermal layer in roots, and is involved in defence against penetrating pathogens. A forward genetic screen identifies a BTB/POZ protein needed for the correct localization and function of PEN3.