Antiviral activity of sirolimus in an HIV-positive kidney transplant recipient. (August 2019)

• Record Type: Journal Article
• Authors: Alfano, Gaetano; Fontana, Francesco; Mori, Giacomo; Vicari, Emanuela; Dolci, Giovanni; Franceschini, Erica; Guaraldi, Giovanni; Mussini, Cristina; Cappelli, Gianni
• Is Part Of: International journal of STD & AIDS. Volume 30:Number 9(2019)
• Page Start: 919
• Page End: 922
• Publication Date: 2019-08
• Subjects: HIV -- sirolimus -- mTORi -- antiretroviral therapy -- kidney transplantation; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462419839520
• Languages: English
• ISSNs: 0956-4624

Abstract

Sirolimus (SIR) is a potent immunosuppressive agent with multiple proprieties. We report beneficial antiviral effects of SIR in an HIV-positive kidney transplant recipient who experienced low-level HIV-1 replication. The immunosuppressive agent was well tolerated by the patient, and no side effects were reported during follow-up. Despite immunosuppressive monotherapy, SIR ensured stable graft function.