Gene masking - a technique to improve accuracy for cancer classification with high dimensionality in microarray data. Issue 3 (December 2016)

• Record Type: Journal Article
• Authors: Saini, Harsh; Lal, Sunil; Naidu, Vimal; Pickering, Vincel; Singh, Gurmeet; Tsunoda, Tatsuhiko; Sharma, Alok
• Is Part Of: BMC medical genomics. Volume 9:Issue 3(2016)
• Page Start: 261
• Page End: 269
• Publication Date: 2016-12
• Subjects: Medical genetics -- Periodicals; Genomics -- Periodicals; 616.042
• DOI: 10.1186/s12920-016-0233-2
• Languages: English
• ISSNs: 1755-8794

Abstract

Abstract Background High dimensional feature space generally degrades classification in several applications. In this paper, we propose a strategy called gene masking, in which non-contributing dimensions are heuristically removed from the data to improve classification accuracy. Methods Gene masking is implemented via a binary encoded genetic algorithm that can be integrated seamlessly with classifiers during the training phase of classification to perform feature selection. It can also be used to discriminate between features that contribute most to the classification, thereby, allowing researchers to isolate features that may have special significance. Results This technique was applied on publicly available datasets whereby it substantially reduced the number of features used for classification while maintaining high accuracies. Conclusion The proposed technique can be extremely useful in feature selection as it heuristically removes non-contributing features to improve the performance of classifiers.