Different body mass index grade on the risk of developing glioma: a meta-analysis. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Dai, Zi-Feng; Huang, Qi-Lin; Liu, Hai-Peng
• Is Part Of: Chinese neurosurgical journal. Volume 1:Issue 1(2015)
• Page Start: 1
• Page End: 6
• Publication Date: 2015-12
• Subjects: Body mass index -- Overweight -- Obesity -- Glioma -- Meta-analysis; Nervous system -- Surgery -- Periodicals; Neurosciences -- Periodicals; 617.48005
• DOI: 10.1186/s41016-015-0008-1
• Languages: English
• ISSNs: 2057-4967

Abstract

Abstract Background Previous studies reported conflicting results about the risk of developing glioma and different body mass index. So we decided to execute a meta-analysis to solve the dispute. Methods Comprehensive literature retrieval was carried in PubMed, MEDLINE, and EMBASE up to September 15, 2014. Hand literature information retrieval was not carried. Six studies were fit for this meta-analysis. Pooled hazard ratio (HR) and 95 % confidence interval (CI) of different body mass index grade were performed by fixed/random-effects models, except for normal weight which was referent. Results Data of 3726 cases were included. Compared with normal weight (20 kg.m−2 < body mass index (BMI) ≤ 24.9 kg.m−2 ), the underweight (BMI ≤ 20 kg.m−2 ) might have lower incidence on the risk of developing glioma (HR = 1.08, 95 % CI ranged 0.74 to 1.58, P = 0.678) . While the overweight (25 kg.m−2 < BMI ≤ 29.9 kg.m−2 ) and obesity (BMI ≥ 30 kg.m−2 ) were performed as a risk factor of developing glioma. The pooled HR of overweight group was 1.12 (95 % CI ranged 1.02 to 1.22, P = 0.013); the pooled HR of obesity was 1.14 (95 % CI ranged 1.02 to 1.27, P = 0.017). Sensitivity analysis approved that our results were stable. There was no publication bias of these studies. Conclusions Underweight could decrease the risk of developing glioma. Excess BMI was considered as a risk factor to develop glioma.