Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors. Issue 21 (30th August 2018)

• Record Type: Journal Article
• Authors: Castillo, Paula M.; Jimenez‐Ruiz, Aila; Carnerero, Jose M.; Prado‐Gotor, Rafael
• Is Part Of: Chemphyschem. Volume 19:Issue 21(2018)
• Page Start: 2810
• Page End: 2828
• Publication Date: 2018-08-30
• Subjects: drug delivery -- drug loading -- nanomedicine -- nanoparticles -- physical chemistry factors; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201800388
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological systems and liberation mechanisms into the target cells, also need to be taken into account. Multiple advantages arise from the use of nanoparticles, such as the capability to solubilize hydrophobic compounds and an increased bioavailability. Those advantages justify the extensive and delicate study that should be undertaken in order to use them as drug delivery agents. One of the most important factors for the design of a drug delivery system with nanoparticles is achieving a high drug‐to‐nanoparticle ratio. In this Minireview, all of these key factors, both physicochemical and biological, are described, and special emphasis is placed on loading methods employed to introduce drugs into nanoparticles. Abstract : Spoilt for choice : When employing nanoparticles in biomedical fields as drug delivery vectors, choosing the right type of nanoparticle and determining the correct procedure for drug loading are critical. In this Minireview, physicochemical factors for nanoparticle choice are reviewed with special emphasis placed on drug loading methods.