Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp. Issue 14 (15th July 2017)

• Record Type: Journal Article
• Authors: Le, Tu Cam; Yim, Chae-Yoon; Park, Songhee; Katila, Nikita; Yang, Inho; Song, Myoung Chong; Yoon, Yeo Joon; Choi, Dong-Young; Choi, Hyukjae; Nam, Sang-Jip; Fenical, William
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 14(2017)
• Page Start: 3123
• Page End: 3126
• Publication Date: 2017-07-15
• Subjects: Lodopyridone -- Saccharomonospora -- BACE1 inhibitor -- Marine natural products; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.05.035
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and2 ) along with the previously reported lodopyridone A (3 ). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3 ). Lodopyridones B and C (1 and2 ) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).