Cytotoxic pterosins from Pteris multifida roots against HCT116 human colon cancer cells. Issue 14 (15th July 2017)

• Record Type: Journal Article
• Authors: Kim, Jung Wha; Kim, Hong Pyo; Sung, Sang Hyun
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 14(2017)
• Page Start: 3144
• Page End: 3147
• Publication Date: 2017-07-15
• Subjects: Pteris multifida -- Pterosin -- Cytotoxicity -- HCT116 cells; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.05.034
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two new pterosin glycosides, (2 S, 3 S )-pterosin C 3- O -β-d -(4′-( E )-caffeoyl)-glucopyranoside (1 ) and (2 S, 3 S )-pterosin C 3- O -β-d -(6′-( E )- p -coumaroyl)-glucopyranoside (2 ), were isolated from Pteris multifida (Pteridaceae) roots along with ten known pterosin compounds (3 –12 ). The chemical structures of the isolated compounds were elucidated by extensive analysis of the 1D, 2D NMR, HRESIMS, and CD spectroscopic data. The cytotoxicities of1 –12 against HCT116 human colorectal cancer cell line were evaluated. Among the isolates, compound1 showed moderate antiproliferative activity in HCT116 cells with an IC50 value of 8.0 ± 1.7 μM. Additionally, 1 induced the upregulation of the caspase-9 and procaspase-9 levels in Western blots and increased the annexin V/propidium iodide (PI)-positive cell population in flow cytometry.