Cytotoxic neo-clerodane diterpenes from Stachys aegyptiaca. (December 2018)

• Record Type: Journal Article
• Authors: Mohamed, Tarik A.; Elshamy, Abdelsamed I.; Hamed, Ahmed R.; Shams, Khaled A.; Hegazy, Mohamed-Elamir F.
• Is Part Of: Phytochemistry letters. Volume 28(2018)
• Page Start: 32
• Page End: 36
• Publication Date: 2018-12
• Subjects: Stachys aegyptiaca -- Lamiaceae -- Neo-clerodane diterpenes -- Stachaegyptin -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2018.09.005
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: From the medicinal herb Stachys aegyptiaca, an organic extract was chemically investigated. Two new diterpenoids were identified via spectroscopic methods. Four purified diterpenoids exhibited cytotoxic activity against a carcinoma cell line. Abstract: Two new E/Z neo -clerodane diterpene isomers, trivially named stachaegyptin D (1 ) and E (2 ), together with known compounds, stachysolon monoacetate (3 ) and stachysolon diacetate (4 ), were isolated from an organic-solvent extract of the medicinal herb Stachys aegyptiaca . Structures were elucidated by a combination of spectroscopic methods, including HREIMS, 1 H, 13 C, DEPT, and 2D NMR analysis, as well as, first time X-ray analysis for stachysolone (3 ). All isolated metabolites showed some activity against the human hepatocellular cell line, HepG2. Compound4 was the most active with an IC50 of 59.5 μM.