Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae. Issue 17 (1st September 2017)

• Record Type: Journal Article
• Authors: Tian, Li-Wen; Feng, Yunjiang; Tran, Trong D.; Shimizu, Yoko; Pfeifer, Tom; Vu, Hoan T.; Quinn, Ronald J.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 17(2017)
• Page Start: 4007
• Page End: 4010
• Publication Date: 2017-09-01
• Subjects: Achyrodimer F -- Cyclobutane derivative -- Tdp1 -- Fungus Cortinariaceae -- DFT calculations; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.07.062
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Mass-guided isolation of the dichloromethane/methanol extracts from a specimen of teleomorphic fungus of the family Cortinariaceae resulted in the identification of a new dimeric cyclobutane metabolite, achyrodimer F (1 ), along with the monomers hispidin (2 ) and bisnoryangonin (3 ). Their structures were determined by NMR and MS data analyses. Density Function Theory (DFT) NMR calculations was employed to confirm the chemical structure of achyrodimer F. Compound1 inhibited tyrosyl-DNA phosphodiesterase I with an IC50 value of 1 μM.