Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma. Issue 6 (13th September 2018)

• Record Type: Journal Article
• Authors: Bosma, Sarah E; van Driel, Pieter BAA; Hogendoorn, Pancras CW; Dijkstra, PD Sander; Sier, Cornelis FM
• Is Part Of: Journal of surgical oncology. Volume 118:Issue 6(2018)
• Page Start: 906
• Page End: 914
• Publication Date: 2018-09-13
• Subjects: CD99 -- cell surface targets -- Ewing sarcoma (ES) -- CXCR4 -- LINGO‐1 -- Image guided surgery; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25224
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract: Ewing sarcoma (ES), an aggressive bone and soft‐tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra‐operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence‐guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra‐operatively, improving complete resection and therefore survival. This review evaluates potential ES‐specific proteins from the literature as targets for NIR FGS.