Treatment for the endocrine resistant breast cancer: Current options and future perspectives. Issue 172 (September 2017)

• Record Type: Journal Article
• Authors: Liu, Chun-Yu; Wu, Chia-Yun; Petrossian, Karineh; Huang, Tzu-Ting; Tseng, Ling-Ming; Chen, Shiuan
• Is Part Of: Journal of steroid biochemistry and molecular biology. Issue 172(2017)
• Page Start: 166
• Page End: 175
• Publication Date: 2017-09
• Subjects: Endocrine resistance -- Hormone receptor -- Estrogen receptor -- Breast cancer; Steroid hormones -- Periodicals; Biochemistry -- Periodicals; Hormones -- Periodicals; Molecular Biology -- Periodicals; Hormones stéroïdes -- Périodiques; Steroid hormones; Periodicals; 572.579
• DOI: 10.1016/j.jsbmb.2017.07.001
• Languages: English
• ISSNs: 0960-0760

Abstract

Highlights: Mechanism of estrogen signaling and the estrogen receptor. Molecular mechanisms of endocrine resistance in breast cancer. Approved treatment options, current treatments and ongoing therapeutic breast cancer clinical trials. Abstract: Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.