Littordial F, a novel phloroglucinol meroterpenoid from the leaves of Psidium littorale. Issue 28 (11th July 2019)

• Record Type: Journal Article
• Authors: Zhu, Hui-Lin; Hu, Yun-Wei; Qu, Wei; Zhang, Jie; Guo, Er-Yan; Jiang, Xue-Yang; Liu, Wen-Yuan; Feng, Feng; Xu, Jian
• Is Part Of: Tetrahedron letters. Volume 60:Issue 28(2019)
• Page Start: 1868
• Page End: 1870
• Publication Date: 2019-07-11
• Subjects: Psidium littorale -- Phloroglucinol meroterpenoid -- Littordial F -- Cytotoxic activity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.06.025
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A novel meroterpenoid with an unique 6/8/9/4-tetracyclic nucleus was isolated. The absolute configuration was confirmed by computational 13 C NMR and optical rotation data. Compound1 exhibited potential cytotoxic activities. Abstract: Littordial F (1 ), a novel meroterpenoid with an unique 6/8/9/4-tetracyclic nucleus, was isolated from the leaves of Psidium littorale . The structure of1 was established by spectroscopic data, and its absolute configuration was confirmed by computational 13 C NMR and optical rotation data. Compound1 exhibited potential cytotoxic activities on A549, B16, and HepG-2 cell lines. A plausible biosynthetic pathway for littordial F was proposed.