The Differentiation of Soft Tissue Infiltration and Surrounding Edema in an Animal Model of Malignant Bone Tumor: Evaluation by Dual-Energy CT. (19th July 2019)

• Record Type: Journal Article
• Authors: Chen, Haisong; Zhang, Yuan; Pang, Jing; Wu, Zengjie; Jia, Meng; Dong, Qian; Xu, Wenjian
• Is Part Of: Technology in cancer research & treatment. Volume 18(2019)
• Publication Date: 2019-07-19
• Subjects: bone neoplasm -- malignant -- edema -- dual energy CT; Oncology -- Periodicals; Cancer -- Diagnosis -- Periodicals; Cancer -- Treatment -- Technological innovations -- Periodicals; 616.994
• DOI: 10.1177/1533033819846842
• Languages: English
• ISSNs: 1533-0346

Abstract

To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft tissues were divided into 3 areas according to pathology and computed tomography images. Computed tomography spectral curve slopes and iodine and water concentrations were assessed. Statistical analyses were performed using the Mann-Whitney U test and t test. The spectral curve of the soft tissue infiltration areas has a slope (1.30 ± 0.41) higher than that of the soft tissue edema areas (0.71 ± 0.23; P < .001). The iodine concentration in the soft tissue infiltration areas (8.56 ± 2.15) was higher than that in the in soft tissue edema areas (6.09 ± 1.02; P < .001). Water concentration was similar in the soft tissue infiltration areas (1033.86 ± 10.50) to that of the edema areas (1031.45 ± 12.83; P < .05). Spectral curve analysis and iodine–water concentration are helpful in the differentiation of bone tumor soft tissue infiltration and soft tissue edema.