Differential effects of gender and patient background diversity on the changes in metabolic and biophysical profiles in people with type-2 diabetes from different ethnicities who fast during Ramadan (H1439); a prospective study from Qatar. (June 2019)

• Record Type: Journal Article
• Authors: Dabbous, Zeinab; Bashir, Mohammed; Elzouki, Abdel-Naser; Ahmed, Mustafa Sid; Farouk, Seleena; Hassanien, Mohamed; Malik, Rayaz A.; Abou Samra, Abdul Badie; Elhadd, Tarik
• Is Part Of: Diabetes research and clinical practice. Volume 152(2019)
• Page Start: 171
• Page End: 176
• Publication Date: 2019-06
• Subjects: Type-2 diabetes -- Ramadan -- Lipids -- Blood pressure -- Ethnicity -- HbA1c; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.03.032
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: This study is the first study to prospectively assess people with type-2 diabetes using complex drug regimens during Ramadan. It involves large number of participants. We assessed the effect of fasting Ramadan on HbA1c, Blood pressure, weight and lipid profile. We compared the effect of fasting on 3 ethnic groups of diabetic people as well as comparing genders. Abstract: Objective: The 'PRO spective Study of dose adjustment of multiple anti-diabetic therapy for Type-2 diabetic patientsFAST ing the Month of Ramadan aimed to assess the biophysical and metabolic effects of fasting during Ramadan, including HbA1c, weight, blood pressure and lipid profile. Study design methods: We performed a prospective study of people with Type-2 diabetes who were on ≥3 drugs for lowering glucose before and after Ramadan of H1438 (May-June 2017) in Hamad Medical Corporation, Qatar. We enrolled 228 participants, of whom 181 completed the study and were included in the analysis. Results: There were 115 (63.5%) men and 66 (36.5%) women, mean age 53.6 ± 9.7 years and mean diabetes duration of 10 ± 6 years. Both HBA1c [7.8% (62 mmol/mol) vs. 7.6% (60 mmol/mol); p = 0.004]; and diastolic BP (75.7 ± 8.55 vs. 68.8 ± 23.1 mmHg, P = 0.001) improved significantly after Ramadan while there was an increase in total cholesterol (3.94 ± 0.89 mmol/l vs 4.11 ± 1.02 mmol/l; p = 0.008) and triglycerides (1.55 ± 0.72 mmol/l vs 1.71 ± 0.9 mmol/l; p = 0.012). Subgroup analysis showed that patients on sulphonylurea, South Asians and males had a significant reduction in both HBA1c and weight. Conclusion: Patients with Type 2 diabetes who fast during Ramadan show an improvement in glycaemic control and diastolic blood pressure, but a worsening of total cholesterol and triglycerides, particularly those of South Asian origin and men.