The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. (June 2019)

• Record Type: Journal Article
• Authors: Micielska, Katarzyna; Gmiat, Anna; Zychowska, Malgorzata; Kozlowska, Marta; Walentukiewicz, Anna; Lysak-Radomska, Anna; Jaworska, Joanna; Rodziewicz, Ewa; Duda-Biernacka, Barbara; Ziemann, Ewa
• Is Part Of: Diabetes research and clinical practice. Volume 152(2019)
• Page Start: 156
• Page End: 165
• Publication Date: 2019-06
• Subjects: Oral glucose tolerance test -- Insulin growth factors -- Heat shock protein -- Insulin resistance -- Decorin; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.05.009
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aim: To investigate the effect of a single and 15 units of high-intensity circuit training (HICT) programme on glucose metabolism, myokines' response and selected genes' expression in women. Methods: Thirty-three, non-active women (mean age: 38 ± 12) were split into a HICT (n = 20) or a control group (CON, n = 13). The training protocol included three circuits of nine exercises with own body weight as a workload performed 3 times a week for five weeks. The CON group performed HICT twice. Blood samples were taken before, 1 h and 24 h after the first and last unit to determine IGF-1, myostatin, irisin, decorin, HSP27, interleukin-15 concentrations using the ELISA immunoenzymatic method. To evaluate HSPB1, TNF-α and DCN mRNA, real-time PCR was used. Pre- and post-intervention, the oral glucose test and body composition assessment were completed. Results: The following parameters tended to decrease after the 5-week HICT program: insulin and HOMA-IR Training diminished insulin/IGF-1 ratio (51% CI: −63% to −34%) and induced the drop of myostatin concentration but significantly only among middle-aged women and at baseline insulin resistance. Conclusion: Obtained data revealed that HICT improved an insulin sensitivity and diminished myostatin concentration among older, insulin-resistant women with lower baseline physical capacity.