"On Water" promoted N-arylation reactions using Cu (0)/myo-inositol catalytic system. Issue 29 (18th July 2019)

• Record Type: Journal Article
• Authors: Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang
• Is Part Of: Tetrahedron letters. Volume 60:Issue 29(2019)
• Page Start: 1938
• Page End: 1941
• Publication Date: 2019-07-18
• Subjects: Myo-inositol -- N-Arylation -- Copper -- Water; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.06.033
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Myo-inositol, a cardiovascular medicine, was used as tridentate O -donor ligand for Cu-catalyzed amination reaction in water. The CN coupling reaction of aryl halides with amines were achieved by Cu powder/myo-inositol catalytic system. The broad scope of substrates was participated in the coupling. Abstract: Myo-inositol is originally applied as a cardiovascular medicine in clinic, which can be multi-ton manufactured via extraction from the byproducts in agricultural product processing such as defatted rice bran and corn-soaking water. Herein, the application of myo-inositol (MI) as a novel versatile tridentate O -donor ligand has been first described for promoting Cu-catalyzed amination reaction in aqueous medium.