The species‐spanning family of LPX‐motif harbouring effector proteins. (17th September 2018)

• Record Type: Journal Article
• Authors: Norkowski, Stefanie; Schmidt, M. Alexander; Rüter, Christian
• Is Part Of: Cellular microbiology. Volume 20:Number 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-17
• Subjects: bacterial effector protein -- E3 ubiquitin ligase -- immunomodulatory -- IpaH -- LPX effector protein family -- type III secretion system; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.12945
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: The delivery of effector proteins into infected eukaryotic cells represents a key virulence feature of many microbial pathogens in order to derail essential cellular processes and effectively counter the host defence system. Although bacterial effectors are truly numerous and exhibit a wide range of biochemical activities, commonalities in terms of protein structure and function shared by many bacterial pathogens exist. Recent progress has shed light on a species‐spanning family of bacterial effectors containing an LPX repeat motif as a subtype of the leucine‐rich repeat superfamily, partially combined with a novel E3 ubiquitin ligase domain. This review highlights the immunomodulatory effects of LPX effector proteins, with particular emphasis on the exploitation of the host ubiquitin system.