Application of TiO2 Nanotubes as a Drug Delivery System for Biomedical Implants: A Critical Overview. Issue 40 (25th October 2018)

• Record Type: Journal Article
• Authors: Kunrath, Marcel F.; Hubler, Roberto; Shinkai, Rosemary S. A.; Teixeira., Eduardo R.
• Is Part Of: ChemistrySelect. Volume 3:Issue 40(2018)
• Page Start: 11180
• Page End: 11189
• Publication Date: 2018-10-25
• Subjects: biomedical implants -- drugs delivery -- drugs release -- surfaces -- TiO2 nanotubes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201801459
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: TiO2 nanotubes (TNTs) surfaces have been applied as a coating to metallic biomedical implants, presenting promising results in preliminary analyses in terms of integration to living tissues when considering cell adhesion and proliferation, physicochemical properties and biocompatibility. They also present the potential to incorporate drugs and regulate their release to the surrounding tissues. Considering this particular potential, a critical review of the latest studies that considered the possible incorporation of specific drugs like antibiotics, anti‐inflammatories and/or proteins and cytokines capable of positively influence the healing process at the implant‐tissue interface has been considered relevant. Also, a summary about TNTs physicochemical characteristics and biocompatibility studies is presented. Advanced methods for regulating this drug‐release mechanism and its specific chemical immobilization in an in vivo environment are discussed, along with TNTs future clinical perspectives. Abstract : TiO2 nanotubes surfaces (TNTs) act from the first biomaterial/cell reaction. Its properties open doors to several therapies with drug delivery system that improve speed/quality of healing as well as prevention of contaminations in this initial contact. Methods of control of drug release (coatings) and external release therapies are alternatives added to these surfaces searching "in situ" performance of these drugs.