Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study. Issue 3 (20th February 2018)

• Record Type: Journal Article
• Authors: Park, Hee Kyung; Ilango, Sindana; Charriez, Christina M.; Checkoway, Harvey; Riley, David; Standaert, David G.; Bordelon, Yvette; Shprecher, David R.; Reich, Stephen G.; Hall, Deborah; Kluger, Benzi; Marras, Connie; Jankovic, Joseph; Dubinsky, Richard; Litvan, Irene
• Is Part Of: Movement disorders. Volume 33:Issue 3(2018)
• Page Start: 468
• Page End: 472
• Publication Date: 2018-02-20
• Subjects: progressive supranuclear palsy -- parkinsonism -- estrogen -- estrogen replacement therapy -- case‐control study; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.27336
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Background : Studies suggesting a protective effect of estrogen in neurodegenerative diseases prompted us to investigate this relationship in progressive supranuclear palsy (PSP). Methods : This case‐control study evaluated the self‐reported reproductive characteristics and estrogen of 150 women with PSP and 150 age‐matched female controls who participated in the Environmental Genetic‐PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen. Results : There was no association between years of estrogen exposure duration and PSP. There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance ( P = .06). Any exposure to estrogen replacement therapy halved the risk of PSP (odds ratio = 0.52; 95% confidence interval = 0.30‐0.92; P = .03). Among PSP cases, earlier age at menarche was associated with better performance on Hoehn and Yahr stage (β = −0.60; SE = 0.26; P = .02) and Unified Parkinson's Disease Rating Scale II score (β = −5.19; SE = 2.48; P = .04) at clinical examination. Conclusions : This case‐control study suggests a protective role of lifetime estrogen exposure in PSP. Future studies will be needed to confirm this association. © 2018 International Parkinson and Movement Disorder Society