Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD. Issue 2 (7th February 2018)

• Record Type: Journal Article
• Authors: Kato, Harumi; Yamamoto, Kazuhito; Kodaira, Takeshi; Higuchi, Yusuke; Yamamoto, Hideyuki; Saito, Toko; Taji, Hirofumi; Yatabe, Yasushi; Nakamura, Shigeo; Kinoshita, Tomohiro
• Is Part Of: Hematology. Volume 23:Issue 2(2018)
• Page Start: 83
• Page End: 88
• Publication Date: 2018-02-07
• Subjects: Lymphoblastic lymphoma -- T-cell -- immunophenotyping -- hyper-CVAD regimen -- flow cytometry; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1080/10245332.2017.1355421
• Languages: English
• ISSNs: 1024-5332

Abstract

ABSTRACT: Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T ( n = 2), cortical T ( n = 4), and medullary T ( n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.