Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms. Issue 9 (20th October 2016)

• Record Type: Journal Article
• Authors: Trifa, Adrian P.; Bănescu, Claudia; Dima, Delia; Bojan, Anca S.; Tevet, Mihaela; Moldovan, Valeriu G.; Vesa, Ștefan C.; Murat, Meilin; Pop, Ioan V.; Skrypnyk, Cristina; Popp, Radu A.
• Is Part Of: Hematology. Volume 21:Issue 9(2016)
• Page Start: 520
• Page End: 525
• Publication Date: 2016-10-20
• Subjects: BCR-ABL negative myeloproliferative neoplasms -- Oxidative stress -- Genetic polymorphisms; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1080/10245332.2016.1163889
• Languages: English
• ISSNs: 1024-5332

Abstract

Abstract : Objectives : To analyze the relationship between six polymorphisms in genes related to oxidative stress, namely CAT -262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu, GSTM1 and GSTT1 null genotypes, and GSTP1 Ile105Val, and the occurrence of BCR-ABL negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis). Methods : We genotyped for these polymorphisms 328 patients with a known mutation status for JAK2 V617F, MPL and CALR, and 363 controls, using molecular genetics assays. Results : The CAT -262 C>T and GPX1 Pro198Leu polymorphisms were seen significantly less frequently, while the GSTP1 IleVal105 polymorphism was seen significantly more frequently in patients with BCR-ABL negative myeloproliferative neoplasms, regardless of the molecular sub-type (e.g. JAK2 V617F or CALR mutated). Discussion and conclusion : Our study provides evidence that variation in genes related to oxidative stress might modulate the risk of developing BCR-ABL negative myeloproliferative neoplasms.