The Renin-Angiotensin System and Skeletal Muscle. Issue 4 (October 2018)

• Record Type: Journal Article
• Authors: Powers, Scott K.; Morton, Aaron B.; Hyatt, Hayden; Hinkley, Matthew J.
• Is Part Of: Exercise and sport sciences reviews. Volume 46:Issue 4(2018:Oct.)
• Publication Date: 2018-10
• Subjects: muscle atrophy -- diaphragm -- ventilator-induced diaphragm dysfunction -- weaning -- reactive oxygen species; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000158
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : The renin-angiotensin system (RAS) plays a key role in the control of blood pressure and fluid homeostasis. Emerging evidence also reveals that hyperactivity of the RAS contributes to skeletal muscle wasting. This review discusses the key role that the RAS plays in skeletal muscle wasting due to congestive heart failure, chronic kidney disease, and ventilator-induced diaphragmatic wasting. Abstract : The renin-angiotensin system plays a key role in skeletal muscle wasting due to heart failure, chronic kidney disease, and prolonged mechanical ventilation.