Voriconazole Treatment for an Infant With Intractable Candida glabrata Meningitis. Issue 10 (October 2018)

• Record Type: Journal Article
• Authors: Tsakiri, Sophia; Aneji, Chiamaka; Domonoske, Christine; Mazur, Lynnette; Benjamin, Daniel K.; Wootton, Susan H.
• Is Part Of: Pediatric infectious disease journal. Volume 37:Issue 10(2018)
• Publication Date: 2018-10
• Subjects: voriconazole -- Candida glabrata -- meningitis -- infant; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002073
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We report voriconazole levels in an infant with disseminated Candida glabrata infection who received combination antifungal therapy and rescue voriconazole treatment. Serum and cerebrospinal fluid voriconazole levels were higher than anticipated and above target. Dose reduction did not lead to a reduction in the blood or cerebrospinal fluid levels. The patient did not exhibit identifiable drug toxicity.