Comparison of acoustic radiation force impulse elastography and transient elastography for prediction of hepatocellular carcinoma recurrence after radiofrequency ablation. Issue 10 (October 2018)

• Record Type: Journal Article
• Authors: Yoon, Jun Sik; Lee, Yu Rim; Kweon, Young-Oh; Tak, Won Young; Jang, Se Young; Park, Soo Young; Hur, Keun; Park, Jung Gil; Lee, Hye Won; Chun, Jae Min; Han, Young Seok; Lee, Won Kee
• Is Part Of: European journal of gastroenterology & hepatology. Volume 30:Issue 10(2018:Oct.)
• Publication Date: 2018-10
• Subjects: catheter ablation -- carcinoma -- hepatocellular -- elasticity imaging techniques -- liver cirrhosis -- recurrence; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000001170
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : Background: To compare the clinical value of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) for hepatocellular carcinoma (HCC) recurrence prediction after radiofrequency ablation (RFA) and to investigate other predictors of HCC recurrence. Patients and methods: Between 2011 and 2016, 130 patients with HCC who underwent ARFI elastography and TE within 6 months before curative RFA were prospectively enrolled. Independent predictors of HCC recurrence were analyzed separately using ARFI elastography and TE. ARFI elastography and TE accuracy to predict HCC recurrence was determined by receiver operating characteristic curve analysis. Results: Of all included patients (91 men; mean age, 63.5 years; range: 43–84 years), 51 (42.5%) experienced HCC recurrence during the follow-up period (median, 21.9 months). In multivariable analysis using ARFI velocity, serum albumin and ARFI velocity [hazard ratios: 2.873; 95% confidence interval (CI): 1.806–4.571; P <0.001] were independent predictors of recurrence, and in multivariable analysis using TE value, serum albumin and TE value (hazard ratios: 1.028; 95% CI: 1.013–1.043; P <0.001) were independent predictors of recurrence. The area under the receiver operating characteristic curve of ARFI elastography (0.821; 95% CI: 0.747–0.895) was not statistically different from that of TE (0.793; 95% CI: 0.712–0.874) for predicting HCC recurrence ( P =0.827). The optimal ARFI velocity and TE cutoff values were 1.6 m/s and 14 kPa, respectively. Conclusion: ARFI elastography and TE yield comparable predictors of HCC recurrence after RFA. Abstract : Supplemental Digital Content is available in the text.