Meta-Analysis Reveals the Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters. Issue 10 (October 2018)

• Record Type: Journal Article
• Authors: Ianos, Oana; Sari-Minodier, Irène; Villes, Virginie; Lehucher-Michel, Marie-Pascale; Loundou, Anderson; Perrin, Jeanne
• Is Part Of: Journal of occupational and environmental medicine. Volume 60:Issue 10(2018)
• Publication Date: 2018-10
• Subjects: aromatic hydrocarbons -- carbon disulfide -- glycol ethers -- male fertility. -- N -- N-dimethylformamide -- perchlorethylene; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000001422
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objectives: Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solvents. Methods: From the PubMed database, we selected studies analyzing the semen of subjects occupationally exposed to solvents, compared with unexposed controls. The meta-analysis was performed on the various semen parameters analyzed in both populations. Results: Seven studies were included in the study. The meta-analysis revealed a significant decrease in ejaculate volume [standardized mean difference (SMD) = −0.35 (−0.63 to −0.07)] and sperm concentration [SMD = −0.36 (−0.64 to −0.08)] in workers exposed to solvents compared with unexposed controls. Conclusion: Our results highlight the importance of preventing reprotoxic risks to male fertility in the workplace.