ASSOCIATION BETWEEN CHOROIDAL CAVERNS AND CHOROIDAL VASCULAR HYPERPERMEABILITY IN EYES WITH PACHYCHOROID DISEASES. Issue 10 (October 2018)

• Record Type: Journal Article
• Authors: Sakurada, Yoichi; Leong, Belinda C. S.; Parikh, Ravi; Fragiotta, Serena; Freund, K. Bailey
• Is Part Of: Retina. Volume 38:Issue 10(2018)
• Publication Date: 2018-10
• Subjects: choroidal cavern -- choroidal vascular hyperpermeability -- Friedman lipid globules -- pachychoroid -- inner choroid; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002294
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To investigate the association between choroidal caverns, choroidal vascular hyperpermeability (CVH), and pachyvessels in eyes with pachychoroid disease. Methods: This was a retrospective review of swept-source optical coherence tomography and indocyanine green angiography imaging performed on eyes with pachychoroid disease. Results: Imaging from 21 eyes with pachychoroid disease entities (8 eyes with pachychoroid pigment epitheliopathy, 11 eyes with central serous chorioretinopathy, and 3 eyes with pachychoroid neovasculopathy) from 11 patients (mean 49.5 years, male/female: 10/1, all white) was available for review. In all study eyes, pachyvessels traversed the areas of CVH visible in mid- and late-phase indocyanine green angiography. A total of 504 choroidal caverns were identified in 11 study eyes (52%). Of the 504 choroidal caverns, 445 (88%) were seen within the areas of CVH compared with 59 (12%), which were detected outside the areas of CVH ( P < 0.001). Eyes with multiple caverns had an increased choroidal thickness when compared with eyes with ⩽1 cavern ( P < 0.001). Conclusion: Choroidal caverns, found primarily in the areas of indocyanine green angiography CVH traversed by pachyvessels, were detected in 52% of eyes with pachychoroid disease. The presence of choroidal caverns in these cases may indicate a loss of normal choroidal architecture associated with dilated Haller layer veins and increased choroidal thickness. Abstract : In pachychoroid disease, the presence of choroidal caverns may indicate a loss of normal choroidal architecture associated with dilated Haller layer veins and increased choroidal thickness.