Aplastic Anemia as an Immune-mediated Complication of Thymoma: A Case Report. Issue 7 (October 2018)

• Record Type: Journal Article
• Authors: Toret, Ersin; Demirag, Bengü; Köker, Sultan A.; Doyurgan, Onur; Ergin, Malik; Genc, Sinan; Karapinar, Tuba H.; Ay, Yilmaz; Oymak, Yeşim; Vergin, Canan
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 7(2018)
• Publication Date: 2018-10
• Subjects: aplastic anemia -- children -- immunosuppressive therapy -- thymoma; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001140
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Thymomas are the most common masses located in the anterior mediastinum, and they are often associated with autoimmune disorders including myasthenia gravis, polymyositis, and aplastic anemia (AA). Autoreactive T-cell clones generated by the thymoma may lead to autoimmune disorders. We report the case of a 14-year-old boy who was examined for AA, and the underlying cause was determined to be an immune-mediated complication of thymoma. He had no matched sibling donors. He underwent thymectomy, and 3 months later he was treated with immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A. The duration of the IST was determined to be a period of 12 months. He has recently been in complete response condition for 6 months since IST stopped. IST is a successful treatment choice for thymomas associated with AA in childhood.