The Role of Inflammation on Vitamin D Levels in a Cohort of Pediatric Patients With Inflammatory Bowel Disease. Issue 4 (October 2018)

• Record Type: Journal Article
• Authors: Strisciuglio, Caterina; Cenni, Sabrina; Giugliano, Francesca Paola; Miele, Erasmo; Cirillo, Grazia; Martinelli, Massimo; Vitale, Alessandra; Tolone, Carlo; Staiano, Annamaria; Miraglia Del Giudice, Emanuele; Perrone, Laura
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 67:Issue 4(2018)
• Publication Date: 2018-10
• Subjects: free 25-hydroxyvitamin-D -- inflammatory bowel disease -- pediatrics -- total 25-hydroxyvitamin-D -- vitamin D–binding protein; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000002049
• Languages: English
• ISSNs: 0277-2116

Abstract

ABSTRACT: Objectives: Existing studies usually do not measure the free vitamin D in pediatric patients with inflammatory bowel disease (IBD) and not consider the effect of inflammation on vitamin D levels. The aim of our study was to evaluate the concentrations of vitamin D–binding protein (VDBP), total and free 25-hydroxyvitamin-D (25(OH)D), and to correlate these values with the disease activity markers. Methods: Newly diagnosed children with IBD and a group of healthy controls (HCs) were enrolled. VDBP and total and free 25(OH)D levels were measured by enzyme-linked immunosorbent assay and compared using the Student t test. In each patient with IBD, the activity scores of disease and the main inflammation markers were correlated to total and free 25(OH)D levels. C-reactive protein was also measured in the control group, and it was related to VDBP by a linear regression test for all the groups. Results: Fifty-one consecutive children were enrolled: IBD = 33, HC = 18. Levels of total 25(OH)D were higher in HC than in patients with IBD ( P = 0.01). The free/total 25(OH)D ratio was, however, higher in patients with IBD compared to HC ( P < 0.001). Finally, levels of VDBP were lower in patients with IBD than in HC ( P = 0.001). A significant direct correlation was found between the free/total 25(OH)D ratio and the activity index of disease ( r 2 : 0.17; P = 0.01). Moreover, in patients with IBD and controls we found a significant indirect correlation between VDBP and C-reactive protein ( r 2 : 0.12; P = 0.01). Conclusions: Inflammation inversely correlates to VDBP concentrations and patients with IBD, despite their deficiency in total 25(OH)D, have normal or even higher levels of free 25(OH)D.