Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model. (12th April 2011)

• Record Type: Journal Article
• Authors: Chakera, A. H.; Nielsen, B. S.; Madsen, J.; Romer, J.; Kristjansen, P. E. G.; Buch, I.; Binderup, T.; Ingvar, C.; Nalla, A.; Kjaer, A.; Hesse, B.
• Other Names: Pons Francesca Academic Editor.
• Is Part Of: International journal of molecular imaging. Volume 2011(2011)
• Publication Date: 2011-04-12
• Subjects: Molecular diagnosis -- Periodicals; Molecular probes -- Diagnostic use -- Periodicals; Diagnostic imaging -- Periodicals; Molecular Imaging; Diagnostic imaging; Molecular diagnosis; Electronic journals; Periodicals; Periodicals; 616.0757
• DOI: 10.1155/2011/828151
• Languages: English
• ISSNs: 2090-1712

Abstract

Abstract : Aim . To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods . We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion . Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.