Tongue strength in patients with subacute myelo-optico-neuropathy. (January 2018)

• Record Type: Journal Article
• Authors: Yamashita, Satoshi; Nakama, Tatsuya; Ueda, Mitsuharu; Honda, Shoji; Kimura, En; Konagaya, Masaaki; Ando, Yukio
• Is Part Of: Journal of clinical neuroscience. Volume 47(2018)
• Page Start: 84
• Page End: 88
• Publication Date: 2018-01
• Subjects: Subacute myelo-optico-neuropathy (SMON) -- Maximum tongue pressure -- Deglutition -- Amyotrophic lateral sclerosis -- Sporadic inclusion body myositis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2017.10.007
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Subacute myelo-optico-neuropathy (SMON) is caused by overdose oral administration of clioquinol. SMON patients showed a decrease of maximum tongue pressure. Decreases in tongue pressure may be involved in the development of dysphagia in SMON patients. Abstract: Subacute myelo-optico-neuropathy (SMON) is a neurodegenerative disease that may be caused by overdose or prolonged oral administration of clioquinol. Recently, dysphagia has attracted attention as a complication of SMON. To investigate lingual control in SMON, we examined patients with SMON using assessments of maximum tongue pressure, compared with dysphagia-related diseases, such as sporadic inclusion body myositis (sIBM) and amyotrophic lateral sclerosis (ALS), and healthy volunteer. The mean maximum tongue pressure (Pmax ) in patients with SMON was 14.7 ± 5.8 kPa, while it was 33.6 ± 4.4 kPa in the controls. In contrast, the mean Pmax for patients with ALS with or without bulbar involvement was 7.8 ± 2.7 kPa and 34.4 ± 5.7 kPa, respectively, while it was 29.4 ± 8.2 kPa in patients with sIBM. Pmax values correlated with lower limb weakness in SMON patients. Decreases in Pmax may be involved in the development of dysphagia in patients with SMON.