Incidence of poststroke seizures: A meta-analysis. (January 2018)

• Record Type: Journal Article
• Authors: Chan, Lung; Hu, Chaur-Jong; Fan, Yen-Chun; Li, Fang-Yu; Hu, Han-Hwa; Hong, Chien-Tai; Bai, Chyi-Huey
• Is Part Of: Journal of clinical neuroscience. Volume 47(2018)
• Page Start: 347
• Page End: 351
• Publication Date: 2018-01
• Subjects: Seizures -- Stroke -- Meta-analysis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2017.10.088
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: A global, pooled incidence of poststroke seizure. The incidence of poststroke seizure varies due to different definition of late-onset poststroke seizure. Including the seizure within 7–14 days after stroke increases the incidence of poststroke seizure. Abstract: Background: Late-onset poststroke seizure is highly associated with epilepsy but the incidence of it is variable due to different definition and follow-up time. We conducted a meta-analysis to determine the incidence of poststroke seizure and analyze the discrepancies among published studies. Methods: We searched the literature for relevant articles published in English between January 1, 1990, and December 31, 2014, by using the following search terms: "seizures after stroke, " "poststroke seizures, " "epilepsy after stroke, " "poststroke epilepsy, " "incidence, " and "follow-up." Reference lists of the relevant articles were reviewed to identify eligible studies not captured by these terms. Results: Seven relevant cohort studies were identified and analyzed. Incidence density was defined as the number of episodes per 100 person-years. Using the definition of late-onset poststroke seizure as seizure occurring 14 days after a stroke, the incidence density was 1.12 (0.95–1.32) per 100 person-years. For poststroke seizures occurring 7 days after the stroke, the incidence density increased to 3.22 (2.94–3.52) per 100 person-years. Conclusion: Our results are relevant to the epidemiology of late-onset poststroke seizure, with 14 days being the ideal cutoff time point. The pooled incidence density of late-onset poststroke seizure was 1.12 per 100 person-years in 4 cohort studies.