Incidental neuroblastoma with bilateral retinoblastoma: what are the chances?. (4th May 2018)

• Record Type: Journal Article
• Authors: Roelofs, Kelsey; Shaikh, Furqan; Astle, William; Gallie, Brenda L.; Soliman, Sameh E.
• Is Part Of: Ophthalmic genetics. Volume 39:Number 3(2018)
• Page Start: 410
• Page End: 413
• Publication Date: 2018-05-04
• Subjects: Familial -- genetic -- incidentaloma -- mosaicism -- neuroblastoma -- retinoblastoma; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2018.1424208
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: A child with bilateral familial retinoblastoma underwent staging MRI brain and orbit which identified subtle leptomeningeal enhancement, thus prompting an MRI whole body, which revealed a retroperitoneal mass, confirmed on laparoscopic biopsy to be neuroblastoma. This is the first reported case of these two rare embryonal non-central nervous system tumors occurring concurrently. The cause of this concurrence is unknown despite their pathogenic similarities with a chance of 4 cases per 10 billion children aged 1–4 years. Incidental neuroblastomas in infants can regress spontaneously but this child underwent systemic chemotherapy for his retinoblastoma that may have caused regression of the neuroblastoma.