Antibacterial and Antioxidant Properties of the Methanolic Extract of the Stem Bark of Pteleopsis hylodendron (Combretaceae). (20th February 2011)

• Record Type: Journal Article
• Authors: Mokale Kognou, Aristide Laurel; Ngono Ngane, Rosalie Annie; Kuiate, Jules Roger; Koanga Mogtomo, Martin Luther; Tchinda Tiabou, Alembert; Mouokeu, Raymond Simplice; Biyiti, Lucie; Amvam Zollo, Paul Henri
• Other Names: Tsakris Athanassios Academic Editor.
• Is Part Of: Chemotherapy research and practice. Volume 2011(2011)
• Publication Date: 2011-02-20
• Subjects: Chemotherapy -- Periodicals; Drug Therapy; Pharmaceutical Preparations; Chemotherapy; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 615.58
• DOI: 10.1155/2011/218750
• Languages: English
• ISSNs: 2090-2107

Abstract

Abstract : Pteleopsis hylodendron (Combretaceae) is used in Cameroon and West Africa folk medicine for the treatment of various microbial infections (measles, chickenpox, and sexually transmitted diseases). The antibacterial properties of the methanolic extract and fractions from stem bark of Pteleopsis hylodendron were tested against three Gram-positive bacteria and eight Gram-negative bacteria using Agar-well diffusion and Broth microdilution methods. Antioxidant activities of the crude extract and fractions were investigated by DPPH radical scavenging activity and β -carotene-linoleic acid assays. The methanolic extract and some fractions exhibited antibacterial activities that varied between the bacterial species (ID = 0.00–25.00 mm; MIC = 781–12500 μ g/mL and 0.24–1000 μ g/mL). The activity of the crude extract is, however, very weak compared to the reference antibiotics (MIC = 0.125–128 μ g/mL). Two fractions (FE and FF ) showed significant activity (MIC = 0.97 μ g/mL) while S. aureus ATCC 25922 was almost resistant to all the tested fractions. In addition, the crude extract and some fractions showed good antioxidant potential with inhibition values ranging from 17.53 to 98.79%. These results provide promising baseline information for the potential use of this plant as well as some of the fractions in the treatment of infectious diseases and oxidative stress.