Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I. Issue 2 (2006)

• Record Type: Journal Article
• Authors: Takahashi, Yukitoshi; Matsuda, Kazumi; Kubota, Yuko; Shimomura, Jiro; Yamasaki, Etsuko; Kudo, Tatsuya; Fukushima, Katsuyuki; Osaka, Hitoshi; Akasaka, Noriyuki; Imamura, Atsushi; Yamada, Shinji; Kondo, Naomi; Fujiwara, Tateki
• Is Part Of: Clinical & developmental immunology. Volume 13:Issue 2/4(2006)
• Page Start: 381
• Page End: 387
• Publication Date: 2006
• Subjects: Developmental immunology -- Periodicals; Clinical immunology -- Periodicals; Immune System -- immunology -- Periodicals; Immune System -- growth & development -- Periodicals; Immune System Diseases -- immunology -- Periodicals; 571.9638
• DOI: 10.1080/17402520600589522
• Languages: English
• ISSNs: 1740-2522

Abstract

Abstract : Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). The relative risks of HLA class I genotypes for Rasmussen syndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). The relative risks of HLA class I-A and B haplotypes are infinity (A*2601+B*5401), 21.1 (A*2402+B*1501), 13.3 (A*2402+B*4801) and 5.1 (A*2402+B*5201). Some alleles and haplotypes of HLA class I may be the risk factors in Japanese patients. Cross-reactivity of cytotoxic T lymphocytes may contribute to the processes leading from infection to the involvement of CNS.