Copanlisib: An Intravenous Phosphatidylinositol 3-Kinase (PI3K) Inhibitor for the Treatment of Relapsed Follicular Lymphoma. Issue 9 (September 2019)

• Record Type: Journal Article
• Authors: Eltantawy, Adel; Vallejos, Ximena; Sebea, Elrodia; Evans, Kirsten
• Is Part Of: Annals of pharmacotherapy. Volume 53:Issue 9(2019)
• Page Start: 954
• Page End: 958
• Publication Date: 2019-09
• Subjects: copanlisib -- chemotherapy -- drug safety -- hematology -- immunology -- lymphoma -- oncology; Chemotherapy -- Periodicals; Pharmacology -- Periodicals; 615.5805
• DOI: 10.1177/1060028019833992
• Languages: English
• ISSNs: 1060-0280

Abstract

Objective: To review the mechanism of action, clinical efficacy, safety, dosage, administration, and role of copanlisib in the treatment of relapsed follicular lymphoma (FL).Data Sources: Sources of information were identified through searches of PubMed (August 2014 to January 2019) using the key terms copanlisib, Aliqopa, PI3K inhibitor, and BAY 80-6946 . Unpublished abstract information was obtained from the American Society of Clinical Oncology.Study Selection and Data Extraction: Review articles and studies in the English language evaluating the pharmacology, efficacy, and safety of copanlisib were included.Data Synthesis: Copanlisib is the first intravenous phosphatidylinositol 3-kinase (PI3K) inhibitor approved for the treatment of relapsed FL in patients who have received at least 2 prior systemic therapies. The safety and efficacy of copanlisib has been studied in the multicenter, single-arm, phase II CHRONOS-1 study. The results reported for FL patients were an objective response rate of 59%, a complete response of 14%, median duration of response of 22.6 months, and median progression-free survival of 11.2 months. The most common adverse events reported were hyperglycemia and hypertension, which were infusion related and transient.Relevance to Patient Care and Clinical Practice: Copanlisib is unique in that it is a pan–class I PI3K inhibitor with preferential inhibitory activity against the PI3K-α and PI3K-δ isoforms. It has a more favorable safety profile than the other agents in its class with no late-onset toxicities.Conclusions: Copanlisib provides an alternative option for patients with relapsed FL. It is safe and effective and has an acceptable toxicity profile.