Effects of a rehabilitation program on microvascular function of CHD patients assessed by near‐infrared spectroscopy. Issue 11 (12th June 2019)

• Record Type: Journal Article
• Authors: Soares, Rogerio N.; Murias, Juan M.; Saccone, Flavia; Puga, Leopoldo; Moreno, Gustavo; Resnik, Miguel; De Roia, Gabriela F.
• Is Part Of: Physiological reports. Volume 7:Issue 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-06-12
• Subjects: Cardiovascular disease -- microvascular responsiveness -- NIRS -- rehabilitation -- vascular; Physiology -- Periodicals; 571
• DOI: 10.14814/phy2.14145
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: This study aimed to evaluate whether near‐infrared spectroscopy (NIRS)‐derived reperfusion slope would detect the effects of a 12‐week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease (CHD). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 years) underwent 12 weeks of drug treatment and high‐intensity interval training (HIIT), 2 times per week (40 min/session). Microvascular responsiveness was assessed by using NIRS assessment of muscle oxygen saturation (StO2 ) combined with a vascular occlusion test (VOT) (NIRS‐VOT). NIRS‐VOT measures were taken at pre‐ and postintervention, and microvascular responsiveness was evaluated by examining the slope 2 of re‐oxygenation rate (slope 2 StO2 ) and the area under the curve (StO2 AUC ) of StO2 signal following cuff release subsequent to a 5‐min occlusion period. The slope 2 StO2 was significantly steeper after 12 weeks of training (4.8 ± 1.6% sec −1 ) compared to the pretraining (3.1 ± 1.6% sec −1 ) ( P < 0.05). The area under the curve for the change in the % StO2 signal during re‐oxygenation increased significantly from 3494 ± 2372%∙sec at pretraining to 9006 ± 4311%∙sec at post‐training ( P < 0.05). NIRS‐VOT technique detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients. Abstract : Coronary heart disease (CHD) is associated with vascular dysfunction at conduit and microvascular level. Near‐infrared spectroscopy detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients.