The role of organ‐ and function‐preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx. Issue 7 (5th February 2019)

• Record Type: Journal Article
• Authors: Akbaba, Sati; Lang, Kristin; Bulut, Olcay Cem; Held, Thomas; Rieken, Stefan; Plinkert, Peter; Jensen, Alexandra; Herfarth, Klaus; Debus, Juergen; Adeberg, Sebastian
• Is Part Of: Head & neck. Volume 41:Issue 7(2019)
• Page Start: 2208
• Page End: 2214
• Publication Date: 2019-02-05
• Subjects: ACC -- carbon ion -- intensity modulated radiotherapy -- larynx -- larynx preservation; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25678
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx. Methods: Eleven patients with primary ACC of the larynx, who received RT definitely ( n = 5/11) or postoperatively ( n = 6/11), were analyzed regarding survival and treatment‐related toxicity with the focus on functional larynx preservation. Results: Median follow‐up was 45 months. RT offered an excellent 5‐year local control (LC) rate of 100%. Eight of 11 patients were treated with a laryngeal preservation approach (LPA). At last follow‐up, only one of these eight patients developed a local recurrence requiring a total laryngectomy 11 years after treatment. Severe toxicity was uncommon, with only one patient with LPA, requiring a temporary tracheostomy during therapy. Conclusions: RT is an effective treatment method for laryngeal ACC with excellent LC rates, preservation of the laryngeal function and voice formation, representing a valuable therapy alternative to total laryngectomy.