BRAF, A gatekeeper controlling endothelial permeability. (13th May 2019)

• Record Type: Journal Article
• Authors: Declercq, Mathias; Treps, Lucas
• Is Part Of: FEBS journal. Volume 286:Number 12(2019)
• Page Start: 2273
• Page End: 2276
• Publication Date: 2019-05-13
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.14861
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : The RAF/MEK/ERK signal transduction pathway is commonly deregulated in cancer and is activated by various stimuli regulating a variety of cell responses. In wild‐type endothelial cells, upon permeability stimuli, ROKα, RAF1, BRAF, and RAP1 become activated, inducing a cascade of reactions resulting in F‐actin remodeling and increased cell permeability. Here, Dorard et al . showed that BRAF ablated cells had more RAF1/ROKα dimerization and relocalization to VE‐cadherin occurred, ultimately leading to less F‐actin content and reduced vessel permeability.