Melasma: Updates and perspectives. Issue 6 (21st December 2018)

• Record Type: Journal Article
• Authors: Kwon, Soon‐Hyo; Na, Jung‐Im; Choi, Ji‐Young; Park, Kyoung‐Chan
• Other Names: Picardo Mauro guestEditor.; Taïeb Alain guestEditor.
• Is Part Of: Experimental dermatology. Volume 28:Issue 6(2019)
• Page Start: 704
• Page End: 708
• Publication Date: 2018-12-21
• Subjects: histopathology -- melasma -- photoaging -- treatment; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13844
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization and increased mast cell count. We also provide some therapeutic implications based on these findings and a discussion on the latest updates and perspectives regarding treatment.