Isolation and identification of new prenylated acetophenone derivatives from Acronychia oligophlebia. Issue 15 (3rd August 2019)

• Record Type: Journal Article
• Authors: Niu, Qian-Wen; Chen, Neng-Hua; Wu, Zhong-Nan; Luo, Ding; Li, Ying-Ying; Zhang, Yu-Bo; Li, Qing-Guo; Li, Yao-Lan; Wang, Guo-Cai
• Is Part Of: Natural product research. Volume 33:Issue 15(2019)
• Page Start: 2230
• Page End: 2235
• Publication Date: 2019-08-03
• Subjects: Acronychia oligophlebia -- prenylated acetophenone derivatives -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1490902
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new prenylated acetophenone derivatives, acronyculatin P (1 ), acronyculatin Q (2 ), and acronyculatin R (3 ) were isolated from the leaves of Acronychia oligophlebia . Their structures were identified by extensive analyses of spectroscopic data (IR, UV, ESI-HRMS, 1D and 2D NMR) and comparison with the literatures. In addition, the cytotoxic activity against MCF-7 cells of the compounds were evaluated by the MTT assay and the IC50 values were 56.8, 40.4 and 69.1 μM, respectively. Graphical Abstract: