Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii. Issue 16 (18th August 2019)

• Record Type: Journal Article
• Authors: Jiang, Hao-Wen; Gu, Shan-Shan; Cao, Lei; Jiang, Sheng-Shi; Lin, Jing; Chen, Yan; Wang, Ling; Jiao, He; Li, Jing-Ya; Zhao, Wei-Min; Li, Jin-Long
• Is Part Of: Natural product research. Volume 33:Issue 16(2019)
• Page Start: 2314
• Page End: 2321
• Publication Date: 2019-08-18
• Subjects: Cynanchum wilfordii -- acetophenones -- hepatic gluconeogenesis -- hypoglycemic; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1443100
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new acetophenones, named cynwilforones A–C (1 –3 ), together with cynandione A (4 ) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds1 and4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro . Abstract :