Aspergilolide, a steroid lactone produced by an endophytic fungus Aspergillus sp. MBL1612 isolated from Paeonia ostii. Issue 15 (3rd August 2019)

• Record Type: Journal Article
• Authors: Zhang, Pei-Liang; Wang, Gang; Xu, Feng-Qing; Liu, Jin-Song; Wang, Ju-Tao; Zhang, Rui; Liu, Hai-Tao; Hu, Jiang-Miao; Wang, Guo-Kai; Wu, Pei-Yun
• Is Part Of: Natural product research. Volume 33:Issue 15(2019)
• Page Start: 2133
• Page End: 2138
• Publication Date: 2019-08-03
• Subjects: Edophytic fungus -- Aspergillus sp. MBL1612 -- aspergilolide -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1488706
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new steroid lactone aspergilolide (1 ), and nine known compounds helvolic acid (2 ), verruculogen (3 ), tryprostatin B (4 ), 13-oxofumitremorgin B (5 ), fumitremorgin C (6 ), demethoxy fumitremorgin C (7 ), terezine D (8 ), aszonalenin (9 ), 12, 13-dihydroxy-fumitremorgin C (10 ) from cultures of the endophytic fungus Aspergillus sp . MBL1612. Their chemical structures were determined by a series of extensive spectroscopic methods. All of the compounds were isolated from this genus for the first time. The cytotoxicity against five human cancer cell lines of new compound were detected.