Balanced between order and disorder: a new phase in transcription elongation control and beyond. Issue 3 (27th May 2019)

• Record Type: Journal Article
• Authors: Lu, Huasong; Liu, Rongdiao; Zhou, Qiang
• Is Part Of: Transcription. Volume 10:Issue 3(2019)
• Page Start: 157
• Page End: 163
• Publication Date: 2019-05-27
• Subjects: Phase separation -- transcriptional control -- P-TEFb -- RNA polymerase II CTD -- transcription elongation; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2019.1570812
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: We recently reported that the cyclin T1 histidine-rich domain creates a phase-separated environment to promote hyperphosphorylation of RNA polymerase II C-terminal domain and robust transcriptional elongation by P-TEFb. Here, we discuss this and several other recent discoveries to demonstrate that phase separation is important for controlling various aspects of transcription.