Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata. Issue 15 (3rd August 2019)

• Record Type: Journal Article
• Authors: Yuwen, Huansha; Yuan, Yuxi; Hao, Xiaojiang; He, Hongping; Zhang, Yu
• Is Part Of: Natural product research. Volume 33:Issue 15(2019)
• Page Start: 2139
• Page End: 2144
• Publication Date: 2019-08-03
• Subjects: Tabernaemontana divaricata -- tabervarine A -- tabervarine B -- monoterpenoid indole alkaloids; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1488707
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new monoterpenoid indole alkaloids, tabervarines A (1 ) and B (2 ), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated. Abstract :