The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Óbice, A.L.S.; Correa, M.G.; Feng, H.S.; Ribeiro, F.V.; Cirano, F.R.; Casati, M.Z.; Pimentel, S.P.
• Is Part Of: International journal of oral & maxillofacial surgery. Volume 48:Issue 7(2019:Jul.)
• Page Start: 962
• Page End: 970
• Publication Date: 2019-07
• Subjects: dental implants -- dental abutment -- surface treatment -- bone -- biological markers -- protein array; Mouth -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Dentistry -- Periodicals; Dentistry, Operative; Oral Surgical Procedures; Surgery, Oral; Dentistry; Maxilla -- Surgery; Mouth -- Surgery; Electronic journals; Periodicals; 617.52059
• DOI: 10.1016/j.ijom.2018.12.012
• Languages: English
• ISSNs: 0901-5027

Abstract

Abstract: The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days. Inter-group comparisons indicated higher levels of EGF, BMP-9, ET-1, FGF, and PlGF in the test group after 30 days ( P < 0.05). PlGF levels were also higher in the test group after 60 days. In the test group, intra-group analysis revealed different levels of ET-1 and FGF between days 3 and 30, and days 3 and 60 ( P < 0.05); furthermore, VEGF levels were significantly higher on day 60 than on day 3 ( P < 0.05). In the control group, intra-group analysis demonstrated significantly different levels of ET-1, FGF, and PlGF between days 3 and 60 and of PlGF between days 14 and 60 ( P < 0.05). In conclusion, abutment surfaces treated with TiO2 influenced the levels of angiogenesis and bone-related markers.