Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Arai, Taeang; Atsukawa, Masanori; Tsubota, Akihito; Koeda, Mai; Yoshida, Yuji; Okubo, Tomomi; Nakagawa, Ai; Itokawa, Norio; Kondo, Chisa; Nakatsuka, Katsuhisa; Masu, Takushi; Kato, Keizo; Shimada, Noritomo; Hatori, Tsutomu; Emoto, Naoya; Kage, Masayoshi; Iwakiri, Katsuhiko
• Is Part Of: Digestive and liver disease. Volume 51:Issue 7(2019)
• Page Start: 1036
• Page End: 1042
• Publication Date: 2019-07
• Subjects: Histopathological liver severity -- NAFLD -- Vitamin D receptor gene; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2018.12.022
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. Aims: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. Methods: SNPs in CYP2R1, DHCR7, vitamin D binding protein ( GC ), CYP27B1, and vitamin D receptor ( VDR ) were determined for 229 consecutive patients with biopsy-proven NAFLD. Results: In this study, vitamin D deficiency defined as 25-hydroxyvitamin-D3 levels of ≤20 ng/mL was found in 151 patients (65.9%). Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Old age ( p = 5.05 × 10 −8 ), high body mass index ( p = 2.13 × 10 −2 ), low total-cholesterol ( p = 1.46 × 10 −4 ), low serum vitamin D level ( p = 7.34 × 10 −3 ), and VDR rs1544410 genotype CC ( p = 9.15 × 10 −3 ) were independent factors associated with advanced liver fibrosis. Conclusion: Serum 25-hydroxyvitamin-D3 levels and the VDR gene SNP were significantly and independently associated with the severity of liver fibrosis in patients with biopsy-proven NAFLD.